Clinical efficacy of "HERPIGEN" in management of the female herpes genitalis Doschanova A.M. - State National Medical University, Almaty AIM: To assess efficacy of "HERPIGEN", an anti-viral preparation in management of females with herpes genitalis. Materials and methods 22 females aged from 21 to 38 with clinical implications of herpetic viral infection comprised the group under observation. The infection presence was confirmed by the performed DNA PCR analysis. The patients’ complaints and medical histories were studied with the examination of immunological status (A-, G- and M-class immunoglobulins). The PCR was employed in herpetic virus typing. We managed to assess the preparation efficacy, side effects and complications, presence or absence of ulcerous erosions and recurrence rate of herpetic viral infection. Method of administration The performed monotherapy comprised spraying of the skin surface and mucous membranes with "HERPIGEN" 6 times a day for 5-7 days. The females were followed-up 7-10 days after the therapy and further with onemonth interval for 6 months. Patients’ characteristics: 22 females with clinical implications of herpetic viral infection in exacerbation were examined and managed on the outpatient basis. All the females above had recurring herpes genitalis with various disease duration: the one of less than one year (n=14), from 1 to 5 years (n=6), 6-10 years (n=2). The disease recurrence rate was as follows: once a month (n=5), one time per two months (n=8), one times per three months (n=9). In 7 of 22 patients the rash was registered accompanied by hyperthermia (up to 37.5 degrees of Centigrade), fever, general indisposition and regional lymphadenitis. Results: the findings of the performed clinical trial are indicative of high "HERPIGEN" efficacy in management of herpetic infections. 20 patients stopped complaining of itch and burning on the 2nd day of the therapy. The reduction of the complaints was observed in 2 females to terminate in all of the patients on the 3rd day of the therapy. First intention and herpetic erosion epithelization were detected to take place on the 2nd day and in the first 3 days of the therapy, respectively. The clinical effect absence was not registered in the management of herpetic affections. The increase in serum IgM was found. Reexamination a month after the therapy revealed no herpes simplex virus in 10 patients, 6 months after the therapy – in 5 more females. 6-month follow-up showed the recurrences in 5 persons. Neither allergic reactions nor side effects were registered. Conclusion "HERPIGEN" is a highly efficient, handy and tolerable preparation for external use in management of herpetic infection implications, causing no sides effects. The preparation can be recommended for wide use in medical practice. Slides 1. Advantages of administration in pregnancy: The "HERPIGEN INTIM" spray - requires no special medical skills, being handy and easy in use without assistance; - produces rapid therapeutic effect; - being natural, produces no allergic and side reactions; - evokes no skin irritation, producing fine sanitizing effect; - is rapidly absorbed, being easily removed and leaving no stains on clothes; - has no embryotoxic and teratogenic effect with safety confidently experimentally and clinically confirmed. 2. Indication of use · Management of herpes viral infection caused by herpes simplex virus both in acute primary and in recurring course. · Herpes viral infection recurrence prevention. · Management of lichen shingles caused by Varicella –Zoster virus (in complex therapy). · Therapy of cytomegalovirus. · Management of papillomavirus infection caused by various types (oncogenic included), of human papilloma virus. · Therapy of non-specific colpitis and vaginosis, vaginal microflora normalization. · As prophylactic anti-viral and anti-inflammatory preparation in sexual intercourse 5. Glycyrrhizic acid is a kinase inhibitor. It produces: · Anti-viral effect. · Anti-flammatory effect. · Anti-ulcerous effect · Anti-bacterial (bacteriostatic) effect · Interferogenic effect · Immunemodulating effect · Antipruritic effect · Produces rapid effect · Produces no side effect · Prolongs remission · Is absolute rapidly 6. HERPIGEN Pharmacological peculiarities and mechanism of action. Glycyrrhizic acid is an essential active agent Mechanism of action: Glycyrrhizic acid inhibites DNA and RNA of : · Herpes simplex virus, Varicella –zoster, Hepatitis A virus, Influenza virus, Vesicular stomatitis virus, Human immunodeficiency virus heclst View our presentation by clicking here. We guarantee your satisfaction when you use these products together. If you are not satisfied, just return the unused portions for a full purchase price refund within 90 days of purchase. Shipping is not refunded. These are our lowest prices ever. Sale ends soon! All packaging is discreet and customer privacy is maintained. LOWEST PRICE GUARANTEE: We will refund 100% of the difference if you find the same products at a lower price within 30 days of purchase. For customers outside the US: Your local authorities may charge you import duties. Biogetica is not responsible for paying these. Please check with your local authorities before placing an order. 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